Objectives-Organic acid anhydrides are potential sensitisers and cause occupational airway diseases.
In an intervention study the efficacy of measures of hygiene at the workplace and possible selection bias were investigated.
Methods-A first investigation with 110 workers exposed to hexahydrophthalic acid anhydride (HHPA) and methyltetrahydrophthalic acid anhydride (MTHPA) was carried out in July 1991.
The results (skin prick test, specific serum IgE) showed that 20 people were sensitised, and in a challenge test the clinical relevance of the sensitisation was confirmed in six subjects.
In December 1991, the hygiene conditions at the plant were improved.
In November 1995 a second investigation of 84 people was performed (anamnesis, skin prick test, specific IgE, spirometry, and ambient and biological monitoring).
The 27 people who had left the plant in the meantime were asked their reasons for leaving.
The relative risk of people sensitised in 1991 of leaving the plant between 1991 and 1995 was 2.6 (95% confidence interval (95% CI) 1.4 to 4.9) compared with people without any sign of sensitisation.
The percentage of people identified as sensitised in 1991, who were still working at the plant and came to the second investigation, was higher than for people without evidence of sensitisation (10/10 v 47/73 ; p<0.05).
In all the 10 sensitised people in 1991 the findings of the first investigation were confirmed in 1995.
The rate of sensitisation in 1995 was 21%. (...)
Mots-clés Pascal : Exposition professionnelle, Médecine travail, Anhydride organique, Industrie chimique, Homme, Allergie, Appareil respiratoire pathologie, Hygiène travail, Condition travail, Sensibilisation, Etude longitudinale, Prévalence, Biais méthodologique, Echantillonnage, Teneur air ambiant, Lieu travail, Immunopathologie
Mots-clés Pascal anglais : Occupational exposure, Occupational medicine, Organic anhydride, Chemical industry, Human, Allergy, Respiratory disease, Occupational hygiene, Working condition, Sensitization, Follow up study, Prevalence, Methodological bias, Sampling, Ambient air concentration, Work place, Immunopathology
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0160300
Code Inist : 002B03L06. Création : 16/11/1999.