A balanced discussion on the ethics of randomized clinical trials should not he based on a single ethical aspect such as respect for the patient's autonomy.
Rather, the analysis should consider the four ethical principles-respect for autonomy, non-maleficence. beneficence, and justice-as applicable to all groups of persons concerned.
We present the ethical benefits and costs of the present practice of randomized clinical trials for four groups : patients involved in clinical trials, patients not involved in trials, participating physicians and society.
The ALARA (As Low As Reasonably Achievable) approach is then introduced and practical measures to achieve a positiv e balance between ethical benefits and costs of randomized trials are proposed.
Mots-clés Pascal : Essai clinique, Randomisation, Ethique, Analyse avantage coût
Mots-clés Pascal anglais : Clinical trial, Randomization, Ethics, Cost benefit analysis
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0160051
Code Inist : 002B30A09. Création : 16/11/1999.