Anemia is a manifestation of lead toxicity.
However, there are conflicting reports of its prevalence among lead-exposed workers, and it is uncertain whether they should be monitored by periodic hemoglobin (Hb) examinations.
To explore the relationship between Hb and lead exposure, we examined the correlation between Hb, blood lead (PbB), and zinc protoporphyrin (ZPP) levels in 961 blood samples obtained from 94 workers in a lead-acid battery plant in Israel between 1980 and 1993.
Blood lead levels exceeded 60 mug/dL (2.90 mumol/L) in 105 (14%) of the blood samples, The correlation between PbB and logZPP was 0.594.
Hb levels did not correlate with PbB or ZPP.
We conclude that (a) periodic Hb determinations are not a useful indicator of lead exposure in Israeli industrial workers ; (b) the discrepancies between the reported correlation between PbB and Hb levels remain unexplained and in need of further study, and (c) a finding of anemia in a person with PbB levels of up to 80 mug/dL should be considered to be due to lead toxicity only after other causes for anemia have been excluded.
Mots-clés Pascal : Exposition professionnelle, Médecine travail, Plomb, Métal lourd, Industrie chimique, Anémie, Surveillance biologique, Pile acide, Marqueur biologique, Sang, Liquide biologique, Hémoglobinémie, Corrélation, Etude longitudinale, Etude cohorte, Homme, Toxicité, Hémopathie
Mots-clés Pascal anglais : Occupational exposure, Occupational medicine, Lead, Heavy metal, Chemical industry, Anemia, Biological monitoring, Acidic cell, Biological marker, Blood, Biological fluid, Hemoglobinemia, Correlation, Follow up study, Cohort study, Human, Toxicity, Hemopathy
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0160026
Code Inist : 002B03L05. Création : 16/11/1999.