The aims of this study were (a) to assess blood cadmium (B-Cd) concentrations and to establish a tentative reference interval ; (b) to identify significant determinants of B-Cd, in a population from Umbria, Central Italy, which was not occupationally exposed to cadmium (Cd).
Four hundred and thirty-four healthy blood-donors volunteered to answer a questionnaire and provide a blood sample for B-Cd analysis, which was performed by graphite furnace atomic absorption spectrophotometry.
Blood Cd concentrations ranged from non-detectable values, i.e. below 0.1 mug/l up to 3.4 mug/l and were not normally distributed.
The median values and the 95th percentiles were 0.7 and 2.0 mug/l, respectively.
Concentrations of B-Cd were more than double in smokers than in non-smokers, median values being 1.1 mug/l and 0.5 mug/l, respectively.
In current smokers, B-Cd values correlated with the number of cigarettes smoked daily (rs=0.40, P=0.0001) and with the cumulative exposure to cigarette smoke (rs=0.35, P=0.0001).
Concentrations of B-Cd correlated with age in the non-smokers, but not in the smokers and were significantly higher in women than in men only in the non-smokers.
Both in smokers and non-smokers, B-Cd concentrations were similar in subjects living in urban or in rural areas.
In the whole study population the lower and the upper tentative reference limit were<0.1 and 2.2 mug/l, respectively, as computed by a non-parametric rank-based method. (...)
Mots-clés Pascal : Cadmium, Métal lourd, Epidémiologie, Taux, Sang, Liquide biologique, Homme, Italie, Europe, Polluant, Environnement, Analyse quantitative
Mots-clés Pascal anglais : Cadmium, Heavy metal, Epidemiology, Rate, Blood, Biological fluid, Human, Italy, Europe, Pollutant, Environment, Quantitative analysis
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0159804
Code Inist : 002B03M01. Création : 16/11/1999.