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  1. Modulating influence of cytochrome P-450 MspI polymorphism on serum liver function profiles in coke oven workers.

    Article - En anglais

    Objectives-It was reported previously that topside oven workers with heavy exposure to coke oven emissions had increased serum activities of hepatic aminotransferase in one coke oven plant.

    This study was conducted to investigate the modifying effect of CYPIAI MspI polymorphism on liver function profiles in coke oven workers.

    Methods-88 coke oven workers from a large steel company in Taiwan were studied in 1995-6.

    Exposure was categorised by work area : topside oven workers and sideoven workers.

    Liver function profiles including serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), r-glutamyl transpeptidase (GGT), alkaline phosphatase (ALP), and total bilirubin (BIL) were examined in the morning after personal exposure measurements.

    The MspI polymorphism was determined by polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP).

    Results

    Five of 23 (22%) topside oven workers and seven of 65 (11%) sideoven workers had the CYPIAI MspI homozygous variant genotype.

    With sideoven workers with the combined wild type and heterozygous variant as the reference group in multiple regression models, it was found that topside oven workers with the combined traits had mean AST and ALT activities that were 21% and 46% higher (95% confidence interval (95% CI) 4% to 42% and 12% to 91%, respectively) than the reference group after adjusting for appropriate confounders. (...)

    Mots-clés Pascal : Exposition professionnelle, Médecine travail, Gaz cokerie, Industrie métallurgique, Homme, Toxicité, Fonction hépatique, Cytochrome P450, Isozyme, Polymorphisme, Génotype, Surveillance biologique, Cytochrome CYP1A1

    Mots-clés Pascal anglais : Occupational exposure, Occupational medicine, Coke oven gas, Metallurgical industry, Human, Toxicity, Liver function, Cytochrome P450, Isozyme, Polymorphism, Genotype, Biological monitoring

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 99-0158368

    Code Inist : 002B03L02. Création : 16/11/1999.