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  1. Is the prevalence of the factor V Leiden mutation in patients with pulmonary embolism and deep vein thrombosis really different ?

    Article - En anglais

    Introduction

    Previous investigations have suggested a lower prevalence of the factor V Leiden mutation in patients with pulmonary embolism, as compared to patients with deep leg vein thrombosis.

    Methods

    We studied unselected patients with pulmonary embolism, in whom we also assessed the presence of deep vein thrombosis by ultrasonography.

    We assessed the prevalence of heterozygosity for the factor V Leiden mutation and compared the outcome of patients with a normal ultrasound (primary pulmonary embolism) to those with an abnormal ultrasound (combined form of venous thromboembolism).

    Furthermore, we performed a literature search to identify all articles regarding the prevalence of heterozygous factor V Leiden mutation in patients with primary deep vein thrombosis, primary pulmonary embolism and a combined form of venous thromboembolism.

    We calculated a (common) odds ratio for these 3 manifestations of venous thromboembolism, including the current findings.

    Results

    In 92 patients with proven pulmonary embolism.

    25 (27%) had also an abnormal ultrasound.

    In these patients, the prevalence of the factor V Leiden mutation was 24% (95% Cl 9% - 45%), whereas the mutation was present in 5 of 67 patients with primary pulmonary embolism (7% ; 95% Cl 2% - 16%). (...)

    Mots-clés Pascal : Thrombose profonde, Veine, Embolie pulmonaire, Facteur V Leiden, Résistance, Protein C (activated), Serine endopeptidases, Peptidases, Hydrolases, Enzyme, Prévalence, Epidémiologie, Hétérozygotie, Pays Bas, Europe, Homme, Appareil circulatoire pathologie, Vaisseau sanguin pathologie, Veine pathologie, Appareil respiratoire pathologie, Hémopathie, Coagulopathie, Maladie héréditaire

    Mots-clés Pascal anglais : Deep vein thrombosis, Vein, Pulmonary embolism, Factor V Leiden, Resistance, Protein C (activated), Serine endopeptidases, Peptidases, Hydrolases, Enzyme, Prevalence, Epidemiology, Heterozygosity, Netherlands, Europe, Human, Cardiovascular disease, Vascular disease, Venous disease, Respiratory disease, Hemopathy, Coagulopathy, Genetic disease

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 99-0158063

    Code Inist : 002B19C. Création : 16/11/1999.