To update the mortality experience of a cohort of 8508 workers with potential exposure to acrylamide at three plants in the United States from 1984-94.
Methods-Analyses of standardised mortality ratios (SMR) with national and local rates and relative risk (RR) regression modelling were performed to assess site specific cancer risks by demographic and work history factors, and exposure indicators for acrylamide and muriatic acid.
For the 1925-94 study period, excess and deficit overall mortality risks were found for cancer sites of interest : brain and other central nervous system (CNS) (SMR 0.65,95% confidence interval (95% CI) 0.36 to 1.09), thyroid gland (SMR 2.11,95% CI 0.44 to 6.17), testis and other male genital organs (SMR 0.28,95% CI 0.01 to 1.59), and cancer of the respiratory system (SMR 1.10,95% CI 0.99 to 1.22) ; however, none was significant or associated with exposure to acrylamide.
A previously reported excess mortality risk of cancer of the respiratory system at one plant remained increased among workers with potential exposure to muriatic acid (RR 1.50,95% CI 0.86 to 2.59), but was only slightly increased among workers exposed or unexposed to acrylamide.
In an exploratory exposure-response analysis of rectal, oesophageal, pancreatic, and kidney cancer, we found increased SMRs for some categories of exposure to acrylamide, but little evidence of an exposure-response relation. (...)
Mots-clés Pascal : Exposition professionnelle, Médecine travail, Acrylamide, Industrie chimique, Epidémiologie, Tumeur maligne, Homme, Etats Unis, Amérique du Nord, Amérique, Etude longitudinale, Mortalité, Facteur risque, Etiologie, Teneur air ambiant, Lieu travail, Relation dose réponse
Mots-clés Pascal anglais : Occupational exposure, Occupational medicine, Acrylamide, Chemical industry, Epidemiology, Malignant tumor, Human, United States, North America, America, Follow up study, Mortality, Risk factor, Etiology, Ambient air concentration, Work place, Dose activity relation
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0158040
Code Inist : 002B03L06. Création : 16/11/1999.