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  1. Tetralogy of Fallot : A population-based study of epidemiology, associated malformations and survival in Western Denmark 1984-1992.

    Article - En anglais

    The study describes the epidemiology and mortality of tetralogy of Fallot (TOF) in a population-based study in Western Denmark.

    Ninety-two infants with TOF were born during 1984-1992.

    Prevalence was 3.01 per 10 000 livebirths.

    Karyotype anomalies were present in 12 (13%) and extracardiac malformations in 16 (17%) of the infants.

    Down syndrome, cleft palate, cleft lip and palate and combined skeletal, gastrointestinal and renal lesions (VACTERL association) were prevalent.

    Twenty-four infants died (26% of total), 13 (54%) of the deaths occurring during the first year of life.

    Mortality was significantly increased in infants with extracardiac malformations (50% vs 19%, p<0.05).

    Eighteen deaths (75% of total deaths) occurred before corrective surgery and 7 of these deaths were sudden.

    Extracardiac malformation (s) in infants with TOF is a significant risk factor for death.

    The study stresses the importance of population-based studies for the assesment of mortality from congenital heart malformations.

    Overall mortality may be very different from mortality related to cardiac surgery.

    Mots-clés Pascal : Tétralogie Fallot, Homme, Danemark, Europe, Epidémiologie, Mortalité, Pronostic, Appareil circulatoire pathologie, Cardiopathie, Maladie congénitale

    Mots-clés Pascal anglais : Fallot tetralogy, Human, Denmark, Europe, Epidemiology, Mortality, Prognosis, Cardiovascular disease, Heart disease, Congenital disease

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 99-0156753

    Code Inist : 002B12A08. Création : 16/11/1999.