Background We investigated a large, foodborne outbreak of hepatitis A that occurred in February and March 1997 in Michigan and then extended the investigation to determine whether it was related to sporadic cases reported in other states among persons who had consumed frozen strawberries, the food suspected of causing the outbreak.
Methods The cases of hepatitis A were serologically confirmed.
Epidemiologic studies were conducted in the two states with sufficient numbers of cases, Michigan and Maine.
Hepatitis A virus RNA detected in clinical specimens was sequenced to determine the relatedness of the virus from outbreak-related cases and other cases.
Results A total of 213 cases of hepatitis A were reported from 23 schools in Michigan and 29 cases from 13 schools in Maine, with the median rate of attack ranging from 0.2 to 14 percent.
Hepatitis A was associated with the consumption of frozen strawberries in a case-control study (odds ratio for the disease, 8.3 ; 95 percent confidence interval, 2.1 to 33) and a cohort study (relative risk of infection, 7.5 ; 95 percent confidence interval, 1.1 to 53) in Michigan and in a case-control study in Maine (odds ratio for infection, 3.4 ; 95 percent confidence interval, 1.0 to 14). (...)
Mots-clés Pascal : Hépatite virale A, Virose, Infection, Epidémiologie, Etiopathogénie, Fraise(fruit), Aliment congelé, Consommation alimentaire, Etats Unis, Amérique du Nord, Amérique, Contamination, Homme, Appareil digestif pathologie, Foie pathologie, Alimentation, Prévention
Mots-clés Pascal anglais : Viral hepatitis A, Viral disease, Infection, Epidemiology, Etiopathogenesis, Strawberry, Frozen food, Food intake, United States, North America, America, Contamination, Human, Digestive diseases, Hepatic disease, Feeding, Prevention
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0152806
Code Inist : 002B05C02G. Création : 16/11/1999.