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  1. Incidence of rectosigmoid adenomatous polyps in subjects without prior colorectal adenoma or cancer : a prospective cohort study.

    Article - En anglais

    Background-Subjects without known colorectal adenomas or cancer constitute a large majority of the population where 85% of all cases of colorectal cancer are thought to occur.

    Consequently these people should be considered for screening to decrease mortality from colorectal cancer in the general population.

    Aims-To estimate the incidence rate of rectosigmoid adenomas in these subjects.

    Methods-Subjects without adenomas or cancer at a previous examination which had visualised the rectosigmoid underwent a fibre endoscopy every three years.

    Endoscopic data and population characteristics were collected prospectively.

    Results

    A total of 450 subjects fulfilled the selection criteria ; 287 (64%) underwent at least two examinations, and 163 had three or more.

    At the second examination, with a mean delay of 39 months, the incidence rate of rectosigmoïd adenomas was 1.50% per patient year.

    The rate was 1.75% per patient year (95% CI 0.80-3.33) at the third endoscopy with an additional mean delay of 38 months.

    The cumulative incidence rate at six years was 7.3% (95% CI 4.3-10.3), representing a mean of 1.2% per patient year.

    This rate increased with age and was higher for men than for women after age adjustment (p<0.03).

    Conclusions-The incidence rates are very low compared with those of patients with prior adenomas.

    These results should be considered in establishing rectosigmoid adenoma screening strategies.

    Mots-clés Pascal : Polype adénomateux, Rectosigmoïde, Epidémiologie, Etude cohorte, Incidence, Dépistage, Carcinome, Rectum, Non existence, Evaluation, Homme, France, Europe, Appareil digestif pathologie, Tumeur bénigne, Tumeur maligne, Intestin pathologie, Rectum pathologie

    Mots-clés Pascal anglais : Adenomatous polyp, Rectosigmoid, Epidemiology, Cohort study, Incidence, Medical screening, Carcinoma, Rectum, Non existence, Evaluation, Human, France, Europe, Digestive diseases, Benign neoplasm, Malignant tumor, Intestinal disease, Rectal disease

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 99-0152342

    Code Inist : 002B13B01. Création : 16/11/1999.