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  1. Premature morbidity from cardiovascular and cerebrovascular diseases in women with systemic lupus erythematosus.

    Article - En anglais

    Objective

    To determine rates of morbidity due to cardiovascular and cerebrovascular diseases among women with systemic lupus erythematosus (SLE).

    Methods

    I used the California Hospital Discharge Database, which contains information on all discharges from acute care hospitals in California, to identify women with SLE who had been hospitalized for treatment of either acute myocardial infarction (AMI), congestive heart failure (CHF), or cerebrovascular accident (CVA) from 1991 to 1994.

    I compared the proportions of hospitalizations for each cause among women with SLE with those in a group of women without SLE, for 3 age strata (18-44 years, 45-64 years, and >=65 years).

    Results

    Compared with young women without SLE, young women with SLE were 2.27 times more likely to be hospitalized because of AMI (95% confidence interval [95% CI] 1.08-3.46), 3.80 times more likely to be hospitalized because of CHF (95% CI 2.41-5.19), and 2.05 times more likely to be hospitalized because of CVA (95% CI 1.17-2.93).

    Among middle-aged women with SLE, the frequencies of hospitalization for AMI and CVA did not differ from those of the comparison group, but the risk of hospitalization for CHF was higher (odds ratio [OR] 1.39,95% CI 1.05-1.73).

    Among elderly women with SLE, the risk of hospitalization for AMI was significantly lower (OR 0.70,95% Cl 0.51-0.89), the risk of hospitalization for CHF was higher (OR 1.25,95% Cl 1.01-1. (...)

    Mots-clés Pascal : Lupus érythémateux, Disséminé, Femelle, Epidémiologie, Morbidité, Complication, Infarctus, Myocarde, Age apparition, Accident cérébrovasculaire, Facteur risque, Homme, Insuffisance cardiaque, Peau pathologie, Tissu conjonctif pathologie, Maladie système, Maladie autoimmune, Immunopathologie, Appareil circulatoire pathologie, Cardiopathie coronaire, Myocarde pathologie, Système nerveux pathologie, Système nerveux central pathologie, Encéphale pathologie, Cérébrovasculaire pathologie, Vaisseau sanguin pathologie, Cardiopathie

    Mots-clés Pascal anglais : Lupus erythematosus, Disseminated, Female, Epidemiology, Morbidity, Complication, Infarct, Myocardium, Age of onset, Stroke, Risk factor, Human, Heart failure, Skin disease, Connective tissue disease, Systemic disease, Autoimmune disease, Immunopathology, Cardiovascular disease, Coronary heart disease, Myocardial disease, Nervous system diseases, Central nervous system disease, Cerebral disorder, Cerebrovascular disease, Vascular disease, Heart disease

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 99-0152212

    Code Inist : 002B07. Création : 16/11/1999.