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  1. Determination of carboplatinum and cisplatinum by interfacing HPLC with ICP-MS using ultrasonic nebulisation.

    Article - En anglais

    A novel HPLC technique has been developed for the determination of carboplatinum (II) and cisplatinum (II) which are used for chemotherapy.

    The compounds were separated by a HPLC column.

    The eluent was on-line nebulized into the nebuliser gas flow using ultrasonic nebulisation.

    The resulting aerosol was driven by the nebuliser gas stream through a 30-cm heating path, a 60-cm cooling path for desolvatisation and into the plasma of the ICP-MS.

    The detection was carried out on platinum mass 195Pt.

    Different RP C18 techniques were tested to obtain the best separation and detection results of the two platinum compounds.

    The solvent-generated anion exchanger method was selected as the method with the best handling and sensitivity.

    This technique allows a good separation of the two compounds within 3 min.

    The detection limits for carboplatinum and cisplatinum were 130 and 80 pg, respectively.

    The newly developed system has been applied to study the behaviour of the platinum species under different anion influences in aqueous solutions.

    These investigations are necessary for the future development of an extraction from environmental samples for the two compounds. (...)

    Mots-clés Pascal : Pollution eau, Rejet eau usée, Eau usée urbaine, Déchet hospitalier, Anticancéreux, Platine II Complexe, Méthode analyse, Analyse chimique, Analyse quantitative, Spectrométrie masse, Plasma couplé inductivement, Chromatographie HPLC, Nébulisation ultrasonique, Limite détection, Devenir polluant, Spéciation

    Mots-clés Pascal anglais : Water pollution, Waste water discharge, Urban waste water, Hospital waste, Antineoplastic agent, Platinum II Complexes, Analysis method, Chemical analysis, Quantitative analysis, Mass spectrometry, Inductively coupled plasma, HPLC chromatography, Ultrasonic nebulization, Detection limit, Pollutant behavior, Speciation

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 99-0150440

    Code Inist : 001D16A05C. Création : 16/11/1999.