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  1. Accrual to breast cancer clinical trials at a university-affiliated hospital in Metropolitan Detroit.

    Article - En anglais

    Despite the large number of available studies, most women with breast cancer do not participate in clinical trials, and this is especially true among lower income and minority women.

    In this study the authors surveyed the practice patterns of four medical oncologists who comprised the clinical breast service at a large urban university hospital to develop a better understanding of the clinical trials enrollment process for women with breast cancer.

    Of 136 new female breast cancer patients seen by the four phsycians over a 7-month period, there were 47 women (34%) offered participation in a clinical trial, and 16 women (12%) were eventually enrolled.

    Women who were offered participation were more likely to be younger (p=0.068) and to have earlier stage disease then were women not offered participation (p=0.008).

    Women enrolled into a trial were also more likely to be younger, although this difference was not statistically significant (p=0.114).

    Patient race was not associated with the accrual or enrollment process.

    Over half of the women were not offered participation in clinical trials because of the lack of available studies.

    Further work evaluating the process of patient enrollment and physician and patient barriers is necessary to develop effective strategies for recruitment into breast cancer clinical trials.

    Mots-clés Pascal : Essai clinique, Participation, Minorité, Tumeur maligne, Glande mammaire, Homme, Femelle, Epidémiologie, Stratégie, Recrutement, Glande mammaire pathologie

    Mots-clés Pascal anglais : Clinical trial, Participation, Minority, Malignant tumor, Mammary gland, Human, Female, Epidemiology, Strategy, Recruitment, Mammary gland diseases

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 99-0149623

    Code Inist : 002B20E02. Création : 16/11/1999.