Immunosurveillance and the evaluation of national immunization programmes : a population-based approach.
Mass vaccination can change the epidemiological dynamics of infectious diseases.
It may result in a limited persistence of natural and vaccine-induced immunity and a higher mean age of infection, which may lead to a greater risk of complications.
The epidemiological situation should be monitored and immunosurveillance based on the assessment of specific antibodies against vaccine-preventable diseases in human serum is one of the tools.
In order to estimate the immunity of the Dutch population reliably, a large-scale, population-based, collection of serum samples was established (8359 sera in a nation-wide sampling and 1589 sera from municipalities with low vaccine coverage).
In contrast to collecting residual sera from laboratories, this approach gains extensive information by means of a questionnaire regarding the determinants of the immune status and the risk factors for the transmission of infectious diseases in general.
The population-based approach gives a better guarantee that the data are representative than collecting sera from laboratories does.
Mots-clés Pascal : Programme sanitaire, Homme, Population, Vaccination, Epidémiologie, Prévention, Immunoprophylaxie, Surveillance sanitaire, Immunité, Sérologie, Analyse quantitative, Anticorps, Pays Bas, Europe
Mots-clés Pascal anglais : Sanitary program, Human, Population, Vaccination, Epidemiology, Prevention, Immunoprophylaxis, Sanitary surveillance, Immunity, Serology, Quantitative analysis, Antibody, Netherlands, Europe
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0149197
Code Inist : 002B30A01C. Création : 16/11/1999.