The impact of tumor markers on the outcome of several malignancies is still under debate.
This relative uncertainty leads to a subjective approach to their use.
Monitoring the use of tumor markers is a valuable tool to identify the need for educational policies.
We conducted a survey to evaluate how tumor markers are routinely used in the follow-up of patients with breast, colorectal and ovarian carcinoma.
The former two malignancies are considered in the present paper.
We surveyed 35 Italian hospitals ; 29 (83%, accounting for 26,622 hospital beds) filled in and returned the questionnaire.
Overall, 467,361 tumor marker requests were scrutinized by the surveyed hospitals.
We found a wide variability in the type and number of routinely used markers, the cutoff points chosen, and the clinical decisions taken on the basis of marker results.
In addition, we observed a relative lack of communication between clinicians and clinical pathologists in around 50% of the surveyed hospitals.
In these cases clinical information was not provided to the laboratory and methodological aspects were not communicated to clinicians.
From the findings of the present study we conclude that the cooperation between clinicians and clinical pathologists must improve before guidelines for the use of tumor marker assays can be framed and the compliance with these guidelines can be checked. (...)
Mots-clés Pascal : Tumeur maligne, Côlon, Rectum, Glande mammaire, Marqueur tumoral, Exploration, Indication, Recommandation, Analyse biochimique, Interprétation, Pratique professionnelle, Questionnaire, Etude multicentrique, Italie, Europe, Homme, Appareil digestif pathologie, Intestin pathologie, Côlon pathologie, Rectum pathologie, Glande mammaire pathologie
Mots-clés Pascal anglais : Malignant tumor, Colon, Rectum, Mammary gland, Tumoral marker, Exploration, Indication, Recommendation, Biochemical analysis, Interpretation, Professional practice, Questionnaire, Multicenter study, Italy, Europe, Human, Digestive diseases, Intestinal disease, Colonic disease, Rectal disease, Mammary gland diseases
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0147180
Code Inist : 002B24O06. Création : 16/11/1999.