Background A maximum likelihood method of mixed distribution analysis (MDA) is presented as a method to estimate the prevalence of iron deficiency anaemia (IDA) in Costa Rican infants 12-23 months old.
MDA characterizes the parameters of the admixed distributions of iron deficient anaemics and non-iron-deficient-anaemics (NA) from the frequency distribution of haemoglobin concentration of the total sample population.
Methods Data collected by Lozoff et al. (1986) from 345 Costa Rican infants 12-23 months old were used to estimate the parameters of the IDA and NA haemoglobin distributions determined by MDA and the widely used three-criteria model of iron deficiency.
The estimates of the prevalence of IDA by each of the methods were compared.
The sensitivity and specificity of MDA compared to diagnosis by the three-criteria method were assessed.
Simulations were carried out to assess the comparability of MDA and the three-criteria method in low and high prevalence scenarios.
Results The mean and standard deviation (SD) of the NA haemoglobin distribution determined by both methods was 12.1 ± 1.0 g/dL.
The IDA haemoglobin distribution determined by MDA had a mean and SD of 10.2 ± 1.3 g/dL while the IDA distribution by the three-criteria method had a mean and SD of 10.4 ± 1.3 g/dL.
The prevalences of IDA as estimated by MDA and the three-criteria method were 24% and 29%, respectively.
The sensitivity and specificity of MDA were 95% and 97%, respectively. (...)
Mots-clés Pascal : Anémie ferriprive, Mélange loi probabilité, Analyse statistique, Modèle mathématique, Epidémiologie, Prévalence, Méthodologie, Nourrisson, Homme, Etude comparative, Costa Rica, Amérique Centrale, Amérique, Hémopathie, Sidéropénie
Mots-clés Pascal anglais : Iron deficiency anemia, Mixed distribution, Statistical analysis, Mathematical model, Epidemiology, Prevalence, Methodology, Infant, Human, Comparative study, Costa Rica, Central America, America, Hemopathy, Sideropenia
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0147145
Code Inist : 002B30A01A1. Création : 16/11/1999.