Risk factors for severe respiratory syncytial virus infection leading to hospital admission in children in the western region of The Gambia.
Background Acute lower respiratory tract infections (ALRI) are the major cause of mortality and morbidity in young children worldwide.
Respiratory syncytial virus (RSV) infection is the most important viral cause of severe ALRI but only a small proportion of children infected with this virus develop severe disease.
To identify possible risk factors for severe RSV infection leading to hospital admission we have carried out a case-control study of Gambian children with RSV infection admitted to hospital.
Methods In all, 277 children admitted to three hospitals in the Western Region of The Gambia with lower respiratory tract infection due to RSV were compared with 364 control children matched for age and location of residence who had not been admitted to hospital with an ALRI during the RSV season.
A detailed questionnaire covering a wide range of potential social, environmental and nutritional risk factors was administered to the child's guardian.
Results Cases came from larger or more crowded compounds than controls ; increased risk was particularly associated with greater numbers of children in the age group 3-5 years living in the compound (odds ratio [OR] for >=2 children in the age group 3-5 years=9.1,95% CI : 3.7-28).
Cases were more likely to have a sibling who had died (OR=3.4,95% Cl : 1.7-7).
Controls were more likely to have been exposed to smoke from cooking fires (OR for the mother of cases cooking at least once daily=0.31,95% Cl : 0.14-0.7). (...)
Mots-clés Pascal : Virose, Infection, Appareil respiratoire pathologie, Virus respiratoire syncytial humain, Pneumovirus, Pneumovirinae, Paramyxoviridae, Mononegavirales, Virus, Admission hôpital, Pollution air, Régime alimentaire, Mode de vie, Statut socioéconomique, Epidémiologie, Facteur risque, Enfant, Homme, Gambie, Afrique, Santé et environnement
Mots-clés Pascal anglais : Viral disease, Infection, Respiratory disease, Human respiratory syncytial virus, Pneumovirus, Pneumovirinae, Paramyxoviridae, Mononegavirales, Virus, Hospital admission, Air pollution, Diet, Life style, Socioeconomic status, Epidemiology, Risk factor, Child, Human, Gambia, Africa, Health and environment
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0146828
Code Inist : 002B05C02C. Création : 16/11/1999.