Forty-eight infants received a single dose (720 ELISA units=0.5 ml) of inactivated hepatitis A vaccine at the fifth month of age with booster at the 11th month of age. together with the second and third doses of the vaccines compulsory under Italian law (diphtheria, tetanus, oral polio and hepatitis B).
Overall, the seroconversion rate was 100%. The anti-HAV geometric mean titre (GMT) reached 3.021 mlU/ml in infants born to anti-HAV-negative mothers, but only 399 mlU/ml in infants born to anti-HAV-positive mothers.
Hepatitis A vaccine was immunogenic, safe and well tolerated without significant side-effects.
There seems to be no reason for not including it in childhood vaccination programmes particularly in low endemic HAV areas.
Mots-clés Pascal : Virus hépatite A, Hepatovirus, Picornaviridae, Virus, Nourrisson, Homme, Vaccin, Programme sanitaire, Immunogénicité, Réponse immune, Immunité humorale, Anticorps, Analyse quantitative, Toxicité, Hépatite virale A, Virose, Infection, Appareil digestif pathologie, Foie pathologie, Italie, Europe, Europe Sud
Mots-clés Pascal anglais : Hepatitis A virus, Hepatovirus, Picornaviridae, Virus, Infant, Human, Vaccine, Sanitary program, Immunogenicity, Immune response, Humoral immunity, Antibody, Quantitative analysis, Toxicity, Viral hepatitis A, Viral disease, Infection, Digestive diseases, Hepatic disease, Italy, Europe, Southern Europe
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0146339
Code Inist : 002B05A02. Création : 16/11/1999.