Infants today lose maternal measles antibody sooner than in the past.
This is related to demographic changes in maternal immunization.
Data for rates of decay of maternal antibody and seroconversion after measles vaccination for infants born to naturally immune (Group 1) or vaccinated (Group 2) mothers have been used to evaluate two vaccination schedules : Regime 1, measles mumps rubella (MMR) at I year of age and Regime 2, monovalent measles at 6 months followed by MMR at 15 months of age.
Regime 2 costs less because MMR can be administered at 15 months with the last pentavalent booster.
Months of protection 1000 children aged 0-15 months (child-months of protection) were estimated for infant populations ranging from 0 to 100% Group I for Regimes I and 2. Regime I provides more child-months of protection only for 100% Group I populations.
For the study population Regime 2 provided at least 17% more child-months of protection than Regime 1. Regime 2 provides increased medical and financial benefits in proportion to the number of Group 2 infants in the population and thus is ever more advantageous for today's increasingly vaccinated populations.
Mots-clés Pascal : Rougeole, Virose, Infection, Nourrisson, Homme, Enfant, Programme sanitaire, Vaccination, Calendrier vaccination, Rappel vaccination, Immunoprotection, Analyse coût efficacité, Immunité naturelle, Origine maternelle, Anticorps, Canada, Amérique du Nord, Amérique
Mots-clés Pascal anglais : Measles, Viral disease, Infection, Infant, Human, Child, Sanitary program, Vaccination, Vaccination schedule, Booster vaccination, Immunoprotection, Cost efficiency analysis, Natural immunity, Maternal origin, Antibody, Canada, North America, America
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0145909
Code Inist : 002B05A02. Création : 16/11/1999.