The long-term effectiveness of hepatitis B vaccination was determined in a high-risk group of 105 institutionalized mentally retarded.
All individuals were vaccinated in 1986, with three (0. 1,6 months), four (0. 1. 6 and 12 months) or more doses according to their immune response at month 7, resulting in group 1 (G1), group 2 (G2) and group 3 (G3).
They were annually followed up for five years, after which they received a booster dose.
Eleven years after the initial vaccination, they were again tested for the presence of hepatitis B virus (HBV) serologic markers.
The decline in anti-HBs logtitre over the first five years was 51% for G1 and 45% for G2.
From the booster on month 60 to year 11, the overall decline was 31%. Eleven years after the start of vaccination and six years after the booster. 92% of the individuals had protective antibody levels higher than 10 IU/L, Gl had a geometric mean titre of 2015 IU/L, for G2 this was 245 IU/L. The difference in response to vaccination between the groups did not affect their protection.
Only two vaccinees seroconverted to anti-HBc positivity without becoming carrier or ill.
Long-term protection against HBV by vaccination appears to be excellent.
Mots-clés Pascal : Enfant, Homme, Arriération mentale, Vaccination, Programme sanitaire, Etude longitudinale, Efficacité, Immunité humorale, Anticorps, Analyse quantitative, Hépatite virale B, Virose, Infection, Mongolisme, Appareil digestif pathologie, Foie pathologie, Aberration chromosomique, Aneuploïdie, Maladie congénitale, Belgique, Europe, Déficience intellectuelle, Trouble développement
Mots-clés Pascal anglais : Child, Human, Mental retardation, Vaccination, Sanitary program, Follow up study, Efficiency, Humoral immunity, Antibody, Quantitative analysis, Viral hepatitis B, Viral disease, Infection, Down syndrome, Digestive diseases, Hepatic disease, Chromosomal aberration, Aneuploidy, Congenital disease, Belgium, Europe, Intellectual deficiency, Developmental disorder
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0145707
Code Inist : 002B05A02. Création : 16/11/1999.