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  1. A single dose of an effective whole cell pertussis vaccine does not significantly increase protection in children primed with a less effective vaccine.

    Article - En anglais

    We evaluated if a single dose of a protective whole cell pertussis vaccine given before school entry to children primed with a less effective vaccine would increase their protection.

    A school cohort including 3876 students and a family cohort including 162 children were assessed, Although there was a trend toward increased protection, the better vaccine did not provide a significant improvement.

    These results suggest that a single dose of an effective vaccine given to children primed with a less effective one does not raise the protection to a level similar to that provided by three doses of the better vaccine.

    Mots-clés Pascal : Enfant, Homme, Vaccination, Rappel vaccination, Immunoprotection, Relation dose réponse, Efficacité, Epidémiologie, Prévalence, Milieu familial, Milieu scolaire, Surveillance sanitaire, Coqueluche, Bactériose, Infection, Appareil respiratoire pathologie, Canada, Amérique du Nord, Amérique

    Mots-clés Pascal anglais : Child, Human, Vaccination, Booster vaccination, Immunoprotection, Dose activity relation, Efficiency, Epidemiology, Prevalence, Family environment, School environment, Sanitary surveillance, Whooping cough, Bacteriosis, Infection, Respiratory disease, Canada, North America, America

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 99-0145252

    Code Inist : 002B05A02. Création : 16/11/1999.