A single dose of an effective whole cell pertussis vaccine does not significantly increase protection in children primed with a less effective vaccine.
We evaluated if a single dose of a protective whole cell pertussis vaccine given before school entry to children primed with a less effective vaccine would increase their protection.
A school cohort including 3876 students and a family cohort including 162 children were assessed, Although there was a trend toward increased protection, the better vaccine did not provide a significant improvement.
These results suggest that a single dose of an effective vaccine given to children primed with a less effective one does not raise the protection to a level similar to that provided by three doses of the better vaccine.
Mots-clés Pascal : Enfant, Homme, Vaccination, Rappel vaccination, Immunoprotection, Relation dose réponse, Efficacité, Epidémiologie, Prévalence, Milieu familial, Milieu scolaire, Surveillance sanitaire, Coqueluche, Bactériose, Infection, Appareil respiratoire pathologie, Canada, Amérique du Nord, Amérique
Mots-clés Pascal anglais : Child, Human, Vaccination, Booster vaccination, Immunoprotection, Dose activity relation, Efficiency, Epidemiology, Prevalence, Family environment, School environment, Sanitary surveillance, Whooping cough, Bacteriosis, Infection, Respiratory disease, Canada, North America, America
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0145252
Code Inist : 002B05A02. Création : 16/11/1999.