The relation between endogenous steroid hormones and risk for breast cancer is uncertain.
Measurement of sex hormone levels may identify women at high risk for breast cancer who should consider preventive therapies.
To test the hypothesis that serum concentrations of estradiol and testosterone predict risk for breast cancer.
Prospective case-cohort study.
Four clinical centers in the United States.
97 women with confirmed incident breast cancer and 244 randomly selected controls ; all women were white, 65 years of age or older, and were not receiving estrogen.
Sex-steroid hormone concentrations were assayed by using serum that was collected at baseline and stored at - 190 °C. Risk factors for breast cancer were ascertained by questionnaire.
Incident cases of breast cancer were confirmed by review of medical records during an average period of 3.2 years.
The relative risk for breast cancer in women with the highest concentration of bioavailable estradiol (>=6.83 pmol/L or 1.9 pg/mL) was 3.6 (95% Cl, 1.3 to 10.0) compared with women with the lowest concentration.
The risk for breast cancer in women with the highest concentration of free testosterone compared with those with the lowest concentration was 3.3 (Cl, 1.1 to 10.3).
The estimated incidence of breast cancer per 1000 person-years was 0.4 (Cl, 0.0 to 1. (...)
Mots-clés Pascal : Carcinome, Glande mammaire, Risque élevé, Estradiol, Testostérone, Concentration chimique, Etude cohorte, Randomisation, Dosage, Prévention, Femelle, Homme, Tumeur maligne, Glande mammaire pathologie, Oestrogène
Mots-clés Pascal anglais : Carcinoma, Mammary gland, High risk, Estradiol, Testosterone, Chemical concentration, Cohort study, Randomization, Assay, Prevention, Female, Human, Malignant tumor, Mammary gland diseases, Estrogen
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0141683
Code Inist : 002B20E02. Création : 16/11/1999.