Regional differences in coeliac disease prevalence in Scandinavia ?
According to investigations from the central region of Sweden (Linköping), Norway, and Finland based on antibody screening, the prevalence of coeliac disease (CD) is around 1 : 300 (0.33%). In Denmark surveys in paediatric departments have shown a prevalence of only 1 : 10,000.
The aim of the present study was to study the prevalence of CD in southern Sweden.
From October 1996 to February 1997,1970 healthy blood donors were screened for CD in a serial procedure : first IgA and IgG gliadin antibodies (GA) and then endomysial antibodies in those positive for GA.
One patient had previously known CD.
Two patients had gastrointestinal symptoms and an increased number of intraepithelial lymphocytes, with improvement on a gluten-free diet.
Three of 185 GA-positive blood donors had endomysial antibodies and biopsy-verified CD.
Thus. 4 of 1970 blood donors had classic CD. resulting in a prevalence of 1 : 492 (0.20%) - that is, rather similar to that found in Linköping, Sweden, and in Finland and Norway.
If the two persons with gluten-sensitive diarrhoea were also included, the prevalence was 6 : 1970=1 : 328. or 0.30%. Conclusions : The prevalence of classic CD (1 : 492) in southern Sweden is comparable to that found in the rest of Scandinavia. except for Denmark.
Mots-clés Pascal : Coeliaque maladie, Dépistage, Prévalence, IgA, IgG, Spécificité, Gliadine, Epidémiologie, Homme, Suède, Europe, Appareil digestif pathologie, Intestin pathologie, Malabsorption intestinale, Immunopathologie, Endomysium
Mots-clés Pascal anglais : Coeliac disease, Medical screening, Prevalence, IgA, IgG, Specificity, Gliadin, Epidemiology, Human, Sweden, Europe, Digestive diseases, Intestinal disease, Intestinal malabsorption, Immunopathology
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0141394
Code Inist : 002B30A01A2. Création : 16/11/1999.