Possible advantages and drawbacks of adding Flexible sigmoidoscopy to Hemoccult-II in screening for colorectal cancer : A randomized study.
Flexible sigmoidoscopy (FS) has been recommended as a screening method to reduce mortality from colorectal cancer (CRC).
The present study evaluates the effect of adding FS to the fecal occult blood test Hemoccult-II (H-II) on diagnostic yield of colorectal neoplasia.
A total of 10,978 normal persons aged 50-75 years were invited to participate, 5495 persons being allocated at random to H-Il and FS and 5483 to H-Il alone.
In spite of a lower compliance (40% versus 56%) for the combined procedure, the diagnostic yield of colorectal neoplasia was higher than for H-II alone (12 CRC versus 4 CRC, and 72 large adenomas versus 14).
Within 24-62 months after screening there were fewer CRCs detected after H-II+FS than after H-Il alone.
The stage distribution was less favorable than in screen-detected cases.
One FS may not be an optimal way of screening, but FS deserves to be evaluated in randomized population studies including repeated H-II tests in the control arm.
Mots-clés Pascal : Carcinome, Côlon, Rectum, Dépistage, Recherche, Sang, Fèces, Association, Sigmoïdoscopie, Flexible, Evaluation performance, Homme, Tumeur maligne, Appareil digestif pathologie, Intestin pathologie, Côlon pathologie, Rectum pathologie, Endoscopie
Mots-clés Pascal anglais : Carcinoma, Colon, Rectum, Medical screening, Research, Blood, Feces, Association, Sigmoidoscopy, Flexible, Performance evaluation, Human, Malignant tumor, Digestive diseases, Intestinal disease, Colonic disease, Rectal disease, Endoscopy
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0141240
Code Inist : 002B24E06. Création : 16/11/1999.