Previous reports have suggested an association between birthweight and type 2 diabetes mellitus.
To investigate the association between birthweight and type 2 diabetes in a large cohort of adult women, taking into account potential explanatory factors in childhood and adult life.
Birthweight was ascertained at the end of follow-up.
The Nurses'Health Study, a cohort of 121 701 U.S. women born from 1921 to 1946 who have been followed since 1976.
69 526 women in the Nurses'Health Study who were free of diabetes at baseline and reported their own birthweight on the 1992 questionnaire.
2123 cases of confirmed type 2 diabetes diagnosed from 1976 to 1992.
Low birthweight was associated with increased risk for type 2 diabetes.
Age-adjusted relative risks suggested a reverse J-shape association between birthweight and risk for type 2 diabetes.
However, after adjustment for adult body mass index and maternal history of diabetes, an inverse association across the entire range of birthweight became apparent ; compared with the reference group, relative risks by ascending birthweight category were 1.83 (95% Cl, 1.55 to 2.16) for birthweight less than 5.0 lb, 1.76 (Cl, 1.49 to 2.07) for birthweight 5.0 to 5.5 lb, 1.23 (Cl, 1.11 to 1.37) for birthweight 5.6 to 7.0 lb, 0.95 (Cl, 0.82 to 1.10) for birthweight 8.6 to 10.0 Ib, and 0.83 (Cl, 0.63 to 1. (...)
Mots-clés Pascal : Poids naissance, Etude cohorte, Association, Diabète non insulinodépendant, Facteur risque, Femelle, Prévention, Homme, Appareil génital femelle, Pédiatrie, Endocrinopathie
Mots-clés Pascal anglais : Birth weight, Cohort study, Association, Non insulin dependent diabetes, Risk factor, Female, Prevention, Human, Female genital system, Pediatrics, Endocrinopathy
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0140866
Code Inist : 002B20F02. Création : 16/11/1999.