To determine whether platelet-activating factor-acetylhydrolase activity in fetal plasma obtained at birth from umbilical vessels is different from that in maternal plasma, and (2) to compare platelet-activating factor-acetylhydrolase activity in cord plasma from fetuses with fetal growth restriction (FGR) and those with appropriate growth for gestational age (AGA).
Platelet-activating factor-acetylhydrolase activity was measured in the plasma of 22 nonpregnant healthy women, 16 pregnant women at term during labor, 28 fetuses exhibiting AGA, and seven fetuses with FGR.
Plasma platelet-activating factor-acetylhydrolase activity in normotensive pregnant women at 37-41 weeks'gestation was 28.1 ± 16.6 nmol/mL per minute, which was not statistically different from the activity in nonpregnant women (30.8 ± 11.1 nmol/mL per minute).
Platelet-activating factor-acetylhydrolase activity in venous cord plasma from AGA fetuses was significantly (P<. 01) lower than that in maternal plasma (6.3 ± 2.6 nmol/mL per minute), and there was no difference between the activities found in arterial and venous cord samples.
In FGR fetuses, venous cord platelet-activating factor-acetylhydrolase activity was significantly (P<. 01) higher (12.1 ± 1. (...)
Mots-clés Pascal : Facteur activant thrombocyte, Acetyl-CoA hydrolase, Thiolester hydrolases, Esterases, Hydrolases, Enzyme, Plasma sanguin, Cordon ombilical, Veine ombilicale, Mère, Age gestation, Etude comparative, Activité biologique, Taux, Facteur risque, Foetus, Adulte, Homme, Femme, Epidémiologie, Sang, Vaisseau sanguin
Mots-clés Pascal anglais : Platelet activating factor, Acetyl-CoA hydrolase, Thiolester hydrolases, Esterases, Hydrolases, Enzyme, Blood plasma, Umbilical cord, Umbilical vein, Mother, Gestational age, Comparative study, Biological activity, Rate, Risk factor, Fetus, Adult, Human, Woman, Epidemiology, Blood, Blood vessel
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0131340
Code Inist : 002B20F02. Création : 16/11/1999.