We reevaluate the demographic and metabolic risk factors for ammonium acid urate stones.
Since 1986,23 women and 21 men ranging in age from 20 to 81 years (mean 48.7) were treated for stones partly composed of ammonium acid urate.
Stone composition ranged from 2 to 60% ammonium acid urate (mean 24.1) of the total stone mass.
No patient had a pure ammonium acid urate stone, although 11 (25%) had stones with ammonium acid urate as the predominant crystal.
In the 44 patients 1 or more potential risk factors for ammonium acid urate were identified.
Of the patients 11 (25%) had a history of inflammatory bowel disease with 10 (22.7%) having undergone ileostomy diversion, 6 (13.6%) admitted to a history of significant laxative use or abuse, 18 (40.9%) were morbidly obese, 16 (36.4%) had a history of recurrent urinary tract infections and 9 (20.5%) had a history of recurrent uric acid stones.
Patients clearly at risk for stones with an ammonium acid urate component include those with a history of inflammatory bowel disease and ileostomy diversion or laxative abuse.
Other factors that may potentially enhance ammonium acid urate stone formation include morbid obesity, recurrent uric acid calculi and recurrent urinary tract infection.
A careful history followed by further metabolic evaluation is warranted in these patients.
Mots-clés Pascal : Lithiase, Voie urinaire, Ammonium composé, Urique acide, Incidence, Facteur risque, Métabolisme, Epidémiologie, Homme, Appareil urinaire pathologie, Vessie pathologie, Calcul urinaire
Mots-clés Pascal anglais : Lithiasis, Urinary tract, Ammonium compound, Uric acid, Incidence, Risk factor, Metabolism, Epidemiology, Human, Urinary system disease, Bladder disease, Urinary stone
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0131205
Code Inist : 002B14B. Création : 16/11/1999.