Context Poor muscle strength, functional limitations, and disability often coexist, but whether muscle strength during midlife predicts old age functional ability is not known.
Objective To determine whether hand grip strength measured during midlife predicts old age functional limitations and disability in initially healthy men.
Design and Setting A 25-year prospective cohort study, the Honolulu Heart Program, which began in 1965 among Japanese-American men living on Oahu, Hawaii.
Participants A total of 6089 45-to 68-year-old men who were healthy at baseline and whose maximal hand grip strength was measured from 1965 through 1970.
Altogether, 2259 men died over the follow-up period and 3218 survivors participated in the disability assessment in 1991 through 1993.
Main Outcome Measures Functional limitations including slow customary walking speed (<=0.4 m/s) and inability to rise from a seated position without using the arms, and multiple self-reported upper extremity, mobility, and self-care disability outcomes.
Results After adjustment for multiple potential confounders, risk of functional limitations and disability 25 years later increased as baseline hand grip strength, divided into tertiles, declined.
The odds ratio (OR) of walking speed of 0.4 m/s or slower was 2.87 (95% confidence interval [Cl], 1.76-4.67) in those in the lowest third and 1.79 (95% Cl, 1.14-2.81) in the middle third of grip strength vs those in the highest third. (...)
Mots-clés Pascal : Main, Epreuve effort, Muscle, Evolution, Age 40-49, Personne âgée, Homme, Facteur prédictif, Déficit fonctionnel, Handicap physique, Pronostic, Exploration, Facteur risque, Membre supérieur
Mots-clés Pascal anglais : Hand, Exercise tolerance test, Muscle, Evolution, Age 40-49, Elderly, Human, Predictive factor, Functional deficit, Physical handicap, Prognosis, Exploration, Risk factor, Upper limb
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0130977
Code Inist : 002B30A01C. Création : 16/11/1999.