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  1. Association of antibodies to beta2-glycoprotein 1 with pregnancy loss and pregnancy-induced hypertension : A prospective study in low-risk pregnancy.

    Article - En anglais

    Objective 

    To determine whether higher levels of anti-bêta2-glycoprotein 1 before 25 weeks'gestation are independently associated with either pregnancy loss or pregnancy-induced hypertension.

    Methods 

    Serum samples for the immunoglobulin (Ig) G and IgM isotypes of anti-bêta2-glycoprotein 1, anticardiolipin antibody, and antiphosphatidylserine were collected from 325 low-risk nulliparas who presented for prenatal care before 25 weeks'gestation.

    This cohort was followed prospectively for the development of pregnancy loss and pregnancy-induced hypertension.

    Results 

    The adjusted odds ratios (OR) and 95% confidence intervals (CI) of elevated antiphospholipid antibody levels for pregnancy loss were :

    • IgG anti-bêta2-glycoprotein 1,

    • OR 1.2 (Cl 0.5,2.8) ;

    • IgG anticardiolipin antibody,

    • OR 8.4 (Cl 2.3,31) ;

    • and IgG antiphosphatidylserine,

    • OR 5.2 (Cl 1.4,18.7).

    The relative risks of pregnancy loss for all IgG antiphospholipid antibodies were higher among women who had blood collected after 10 weeks'gestation compared with those studied before 10 weeks'gestation.

    However, there were only marginal differences in the attributable risks, suggesting that the impact of elevated levels of antiphospholipid antibodies might be similar in early and later stages of pregnancy.

    None of the antiphospholipid antibodies was associated with pregnancy-induced hypertension. (...)

    Mots-clés Pascal : Hypertension artérielle, Avortement, Gestation, Anticorps, Glycoprotéine bêta2, Phosphatidylsérine, Taux, Epidémiologie, Facteur risque, Homme, Femelle, Etats Unis, Amérique du Nord, Amérique, Etude comparative, Appareil circulatoire pathologie, Gestation pathologie

    Mots-clés Pascal anglais : Hypertension, Abortion, Pregnancy, Antibody, bêta2 acid-Glycoprotein, Phosphatidylserine, Rate, Epidemiology, Risk factor, Human, Female, United States, North America, America, Comparative study, Cardiovascular disease, Pregnancy disorders

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 99-0130778

    Code Inist : 002B20F01. Création : 16/11/1999.