Extra-hepatic biliary atresia and several other causes of neonatal liver disease carry high mortality and morbidity rates, especially if not treated early in life.
Despite professional recommendations, delayed referral of infants with prolonged jaundice continues to be a significant problem.
One approach to reducing the age of referral and diagnosis is population screening to detect significant conjugated hyperbilirubinaemia as an index of liver dysfunction.
To investigate this possibility, and to provide reference data on bilirubin and its conjugated and unconjugated fractions in a normal newborn population, 1157 neonates were anonymously tested (median age 7 days. range 4-28 days) using surplus plasma from routinely collected neonatal screening specimens. using dry slide chemistry.
Of 2310 specimens received, 50% were suitable for analysis.
The remainder were either haemolysed or insufficient (10% and 40% of the total, respectively).
Total bilirubin concentrations ranged from 9 to 428 mumol/l and conjugated bilirubin from 0 to 175 mumol/l, although the latter was rarely increased to more than 30 mumol/l (2.5th-97.5th percentile ranges 15-285 mumol/l and 0-18 mumol/l, respectively).
The range of the percentage of conjugated bilirubin was 0-57% (2.5th-97.5th percentile : range 0-20%). (...)
Mots-clés Pascal : Atrésie, Voie biliaire, Dépistage, Néonatal, Bilirubine, Forme libre, Forme liée, Symptomatologie, Ictère, Etude statistique, Enfant, Homme, Appareil digestif pathologie, Voie biliaire pathologie, Malformation, Maladie congénitale
Mots-clés Pascal anglais : Atresia, Biliary tract, Medical screening, Neonatal, Bilirubin, Free form, Bound form, Symptomatology, Jaundice, Statistical study, Child, Human, Digestive diseases, Biliary tract disease, Malformation, Congenital disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0129694
Code Inist : 002B13C03. Création : 16/11/1999.