It was recently shown that hand postaxial polydactyly differed from foot postaxial polydactyly.
The aim of this work was to test whether thumb and hallux duplication also had different clinical and epidemiological characteristics, depending on limb involvement.
We studied 920 newborn infants with first digit duplication, ascertained among 3,444,374 births by the Latin-American Collaborative Study of Congenital Malformations (ECLAMC), from 1967 to 1995.
Since biphalangeal thumb duplication or hallux duplication can occur in families with triphalangeal thumb or polysyndactylous propositi, these groups were also analyzed.
The 715 isolated (nonsyndromal) cases (prevalence 2.08 per 10,000) were subdivided into five groups :
thumb duplication (N=568 ; prevalence : 1.65/10,000) ;
hallux duplication (N=82 ; prevalence : 0.24) ;
thumb and/or hallux duplication plus syndactyly (polysyndactyly) (N=37 ; prevalence : 0.11) ;
triphalangeal thumb (N=24 ; prevalence : 0.07), and thumb duplication plus hallux duplication (N=4 ; prevalence : 0.01).
Both thumb and hallux duplication groups showed a significant excess of males, and right sidedness was also more frequent in both of them, though without statistical significance for hallux duplication.
Thumb duplication was more often unilateral (94.7% versus hallux duplication of 81.5%), and its prevalence was higher in Bolivia (3.37/10,000) than in the other 10 Latin-American countries included (1.62/10,000). (...)
Mots-clés Pascal : Polydactylie, Forme clinique, Pouce, Gros orteil, Main, Pied, Nouveau né, Homme, Etude comparative, Triphalangie, Epidémiologie, Etude familiale, Syndactylie, Exploration, Phénotype, Amérique Latine, Amérique, Membre supérieur, Membre inférieur, Système ostéoarticulaire pathologie, Dysostose, Main pathologie, Maladie congénitale, Malformation, Pied pathologie, Maladie héréditaire
Mots-clés Pascal anglais : Polydactyly, Clinical form, Thumb, Big toe, Hand, Foot, Newborn, Human, Comparative study, Triphalangia, Epidemiology, Family study, Syndactyly, Exploration, Phenotype, Latin America, America, Upper limb, Lower limb, Diseases of the osteoarticular system, Dysostosis, Disease of the hand, Congenital disease, Malformation, Disease of the foot, Genetic disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0129460
Code Inist : 002B15H. Création : 16/11/1999.