To measure plasma levels of C-type natriuretic peptide in women with normal pregnancies and those complicated by gestational hypertension and preeclampsia.
We collected venous plasma samples from 20 women with normal pregnancies, 15 with gestational hypertension, and nine with preeclampsia.
Gestational ages ranged from 26-39 weeks.
We measured C-type natriuretic peptide concentrations by radioimmunoassay.
Statistical comparisons were made by one-way analysis of variance and Tukey test.
The mean plasma concentration of C-type natriuretic peptide in the women with normal pregnancy was 7.1 ± 2.5 pg/mL, in those with gestational hypertension 9.6 ± 4.2 pg/mL, and in those with preeclampsia 8.1 ± 2.4 pg/mL.
There were no statistically significant differences between groups.
The statistical power to detect a difference of 3 pg/mL at the 5% significance level was 78% for the group with gestational hypertension and 64% for the preeclamptic group.
Our results suggest that C-type natriuretic peptide plasma levels are not significantly different in normal pregnancies and those complicated by gestational hypertension or preeclampsia, In hypertensive pregnancy disorders, C-type natriuretic peptide showed a distinct course compared with atrial natriuretic peptide and brain natriuretic peptide.
Mots-clés Pascal : Prééclampsie, Hypertension artérielle, Gestation, Hormone natriurétique, Taux, Plasma sanguin, Etude comparative, Facteur risque, Diagnostic, Indicateur, Homme, Femelle, Epidémiologie, Allemagne, Europe, Gestation pathologie, Toxémie gravidique, Appareil circulatoire pathologie, Sang
Mots-clés Pascal anglais : Preeclampsia, Hypertension, Pregnancy, Natriuretic hormone, Rate, Blood plasma, Comparative study, Risk factor, Diagnosis, Indicator, Human, Female, Epidemiology, Germany, Europe, Pregnancy disorders, Pregnancy toxemia, Cardiovascular disease, Blood
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0129396
Code Inist : 002B20F01. Création : 16/11/1999.