To identify virological parameters (serostatus of hepatitis B surface antigen [HBsAg] and antibodies to hepatitis C virus [anti-HCV], HCV genotypes and HCV-RNA titer) and other clinico-biological and lifestyle variables that may influence or predict the development of hepatocellular carcinoma (HCC) in cirrhosis, we followed 100 cirrhotic patients without HCC, who visited Kyushu University Hospital between 1985 and 1987, until the end of 1995 (follow-up rate : 98% ; average follow-up period : 5.3 years).
After elimination of 4 patients who developed HCC or were censored within the initial 6 months, 37 (39%) out of 96 patients developed HCC during follow-up.
As compared with HBsAg (+) patients, anti-HCV (+) HBsAg (-) patients demonstrated significantly elevated HCC risk (adjusted hazard ratio [HR]=5.85,95% confidence interval [CI] 1.65-20.67).
Genotype I HCV infection was not associated with increased risk compared with genotype 2 (HR=0.64,95% CI 0.21-1.99).
For genotype I HCV infection, patients with HCV-RNA levels=1 Meq/ml (P=0.03).
Male sex, advanced Child's class, lower serum albumin, and higher serum aminotransferase and alpha-fetoprotein were also found to be strong predictors.
Overall, drinking and smoking habits were not associated with significantly elevated risk. (...)
Mots-clés Pascal : Cirrhose, Complication, Facteur risque, Carcinome hépatocellulaire, Epidémiologie, Hépatite virale C, Virose, Infection, Virus hépatite C, Hepacivirus, Flaviviridae, Virus, Etude longitudinale, Japon, Asie, Homme, Appareil digestif pathologie, Foie pathologie, Tumeur maligne
Mots-clés Pascal anglais : Cirrhosis, Complication, Risk factor, Hepatocellular carcinoma, Epidemiology, Viral hepatitis C, Viral disease, Infection, Hepatitis C virus, Hepacivirus, Flaviviridae, Virus, Follow up study, Japan, Asia, Human, Digestive diseases, Hepatic disease, Malignant tumor
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0127957
Code Inist : 002B13C01. Création : 16/11/1999.