Congenital cytomegalovirus infection in a northern Italian region.
Knowledge of the prevalence of congenital cytomegalovirus infection is necessary to evaluate the need for prevention.
We performed a multicentre one-year study involving 11 neonatology divisions to ascertain the prevalence in Lombardy.
Cytomegalovirus was isolated by culturing saliva samples from all babies born (n=1268) of two 15-day sample periods and from 185 neonates with suspected congenital CMV based on clinical and laboratory findings and the history.
The overall prevalence of congenital infection was 0.47% (6/1268) in the sample period group and 5% (9/185) in the second group.
Clinical monitoring revealed sequelae in two of three children with symptomatic infection and no asymptomatic child at age two years.
In a subgroup of 205 babies including 14 of the infected infants we also evaluated a test to detect cytomegalovirus DNA in the Guthrie cards obtained in neonatal screening for genetic and metabolic disorders.
The test's sensitivity was 100% and specificity 98.5%, encouraging its use for early identification of infected neonates and for large epidemiological studies.
Mots-clés Pascal : Italie, Europe, Lombardie, Nouveau né, Homme, Epidémiologie, Prévalence, Dépistage, Etude multicentrique, Virose, Infection, Cytomegalovirus humain, Betaherpesvirinae, Herpesviridae, Virus, Congénital, Réaction chaîne polymérase, Test Guthrie, Technique, Biologie moléculaire
Mots-clés Pascal anglais : Italy, Europe, Lombardy, Newborn, Human, Epidemiology, Prevalence, Medical screening, Multicenter study, Viral disease, Infection, Human cytomegalovirus, Betaherpesvirinae, Herpesviridae, Virus, Congenital, Polymerase chain reaction, Guthrie test, Technique, Molecular biology
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0127147
Code Inist : 002B05C02J. Création : 16/11/1999.