8-Hydroxydeoxyguanosine as a biomarker of workplace exposures.
To date, the 8-hydroxydeoxyguanosine (8OHdG) DNA adduct has been used as a biomarker in 11 occupational health studies examining the potential for ten different workplace exposures to cause oxidative DNA damage.
Exposures examined include asbestos, azo-dyes, benzene, chromium, coal dust, glassworks, rubber manufacturing, styrene, toluene and environmental tobacco smoke (ETS).
Experimental designs that applied 8OHdG as biomarker varied dramatically among the studies.
For example, one study detected increased urinary excretion in retired workers with a history of exposure to mining dusts, while a study of workers exposed to benzene showed that the pattern of urinary excretion of 8OHdG varied over a 24 h period following exposure.
All but one study reported increased 8OHdG relative to controls, but in three cases the increases were not statistically significant.
Only one study demonstrated a dose-response relationship between a chemical exposure (benzene) in the workplace and elevated 8OHdG.
In most cases, exposure data were lacking and the elevated 8OHdG could only be considered to be associated with a generalized job category.
Numerous animal and human studies have demonstrated an effect of tobacco smoke on 8OHdG, including a study of ETS in the workplace.
In the majority of occupational studies, however, smoking was found not to be a confounding variable. 8OHdG levels tended to be higher in women than men as did the response to an occupational exposure and/or smoking. (...)
Mots-clés Pascal : Stress oxydatif, Adduit moléculaire, Désoxyribonucléoside, Marqueur biologique, Purine nucléoside, Article synthèse, Médecine travail, Liquide biologique, Urine, Sang, Lymphocyte, Homme, Exposition professionnelle, Toxicité, DNA, Leucocyte, Dépistage, Surveillance biologique, Epidémiologie, Guanosine(2p-désoxy-8-hydroxy)
Mots-clés Pascal anglais : Oxidative stress, Molecular adduct, Deoxyribonucleoside, Biological marker, Purine nucleoside, Review, Occupational medicine, Biological fluid, Urine, Blood, Lymphocyte, Human, Occupational exposure, Toxicity, DNA, Leukocyte, Medical screening, Biological monitoring, Epidemiology
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0126945
Code Inist : 002B03L01. Création : 16/11/1999.