Previous medical history and medications as risk factors for hairy cell leukaemia.
To investigate the possible role of previous medical history and previous medications as risk factors for hairy cell leukaemia (HCL) we performed a population based case-control study on 121 male HCL patients and 484 controls.
The data were collected through a self-administered mailed questionnaire.
Elevated odds ratios (OR) were found for a history of appendicitis [OR 1.9 : 95% confidence interval (CI) 0.9-4.2] and pneumonia (OR 2.9 ; CI 0.9-9.6).
We found a reduced risk for HCL associated with a history of myocardial infarction (OR 0.3 ; CI 0.4-2.5), hypertension (OR 0.6 ; CI 0.3-1.2) and thromboembolic disease (OR 0.6 ; CI 0.1-2.7).
Reduced OR was also associated to a history of diabetes mellitus (OR 0.6 ; CI 0.1-2.9) and a diagnosis of hyperlipidemia (OR 0.8 ; CI 0.2-3.6).
HCL is an indolent disease with a clinical course of many years and it can not be excluded that the disease leads to metabolic changes, resulting in a changed risk for these diagnoses.
When the role of previous medications were investigated, increased OR was found for NSAID (OR 3.4 ; CI 1.1-10.2).
Decreased OR was found for the anti-coagulative agent warfarin (OR 0.4 ; CI 0.1-1.5).
A history of a previous malignancy preceeding the diagnosis of HCL as reported to the Swedish Cancer Registry yielded an increased OR of 3.2 (CI 1.2-8.5).
All results must be interpreted with caution, as there is a possibility of misclassification. (...)
Mots-clés Pascal : Leucémie lymphohistiocytaire, Facteur risque, Antécédent, Appendicite, Diabète, Epidémiologie, Pneumonie, Thrombose, Infarctus, Myocarde, Hyperlipémie, Médicament, Etude cas témoin, Suisse, Europe, Homme, Chronique, Lipide, Hémopathie maligne, Lymphoprolifératif syndrome, Appareil digestif pathologie, Intestin pathologie, Appareil respiratoire pathologie, Poumon pathologie, Appareil circulatoire pathologie, Cardiopathie coronaire, Myocarde pathologie, Métabolisme pathologie, Dyslipémie, Antécédent personnel
Mots-clés Pascal anglais : Hairy cell leukemia, Risk factor, Antecedent, Appendicitis, Diabetes mellitus, Epidemiology, Pneumonia, Thrombosis, Infarct, Myocardium, Hyperlipemia, Drug, Case control study, Switzerland, Europe, Human, Chronic, Lipids, Malignant hemopathy, Lymphoproliferative syndrome, Digestive diseases, Intestinal disease, Respiratory disease, Lung disease, Cardiovascular disease, Coronary heart disease, Myocardial disease, Metabolic diseases, Dyslipemia
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0126287
Code Inist : 002B19B. Création : 16/11/1999.