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  1. Urinary lithium : Distribution shape, reference values, and evaluation of exposure by inductively coupled plasma argon-emission spectrometry.

    Article - En anglais

    Inductively coupled plasma argon-emission spectrometry (ICPAES) was used to evaluate the lithium content of undiluted urine samples.

    The method can be performed with 1 mL of urine in a single tube using a routine ICPAES analysis for rapid and convenient assessment of lithium exposure in humans.

    Urine samples obtained from male workers (n=86) who had not been exposed to lithium were used for the determination of this element by ICPAES.

    The obtained concentrations were corrected using a specific gravity of 1.024.

    The particular frequency distribution resulted in a log-normal distribution diagram for anatomical spread.

    Geometric mean value for urinary lithium in the nonexposed male workers was 23.5 mug/L, and the confidence interval from a log-normal distribution was 11.0 to 50.5 mug/L. Taking into consideration a short biological half-life and the massive urine excretion of lithium, urinary lithium was considered to be a useful index for monitoring of exposure.

    Calibration curves obtained for lithium standards had good sensitivity and linearity.

    Good reproducibility was assessed by lithium addition to urine samples.

    It was concluded that the obtained lithium reference values would be useful for the early diagnosis of lithium intoxication or in the assessment of the degree of exposure to lithium in subjects at risk.

    Mots-clés Pascal : Analyse chimique, Analyse quantitative, Métal alcalin Ion, Lithium Ion, Liquide biologique, Urine, Elimination, Médecine travail, Exposition professionnelle, Industrie électronique, Homme, Mâle, Japon, Asie, Spectrométrie émission, Spectrométrie ICP, Evaluation risque

    Mots-clés Pascal anglais : Chemical analysis, Quantitative analysis, Alkali metal Ions, Lithium Ions, Biological fluid, Urine, Elimination, Occupational medicine, Occupational exposure, Electronics industry, Human, Male, Japan, Asia, Emission spectrometry, Inductive coupling plasma spectrometry, Risk assessment

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 99-0125979

    Code Inist : 002B03L05. Création : 16/11/1999.