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  1. Asymptomatic primary biliary cirrhosis : A study of its natural history and prognosis.

    Article - En anglais

    Objective 

    To document the natural history of asymptomatic primary biliary cirrhosis and identify prognostic features that would predict the development of symptomatic disease.

    Methods 

    A retrospective chart review of all patients with abnormal liver biochemical tests and antimitochondrial antibody-positive, liver biopsy-compatible primary biliary cirrhosis who were seen in a single tertiary care center between 1983 and 1994 was performed.

    Statistical analysis using Cox regression was employed to compare survival of the study population with an age-and gender-matched control population and to identify potential prognostic variables.

    Results 

    Ninety-one patients were included.

    Median age at presentation was 53.2 yr.

    Ninety percent were female.

    Median follow up was 61.2 months (range 7-206 months).

    Thirty-six percent (33 patients) became symptomatic with 11% (10 patients) progressing to death or liver transplant.

    Median predicted length of survival from onset of disease for the entire cohort was 14 yr.

    Patient survival was less than that predicted for an age-and gender-matched control population (p<0.05).

    Univariate and multivariate analysis on a broad spectrum of clinical, biochemical, and histological features at the time of initial presentation failed to reveal any prognostic variables that would distinguish those who would become symptomatic from those who would remain symptom-free. (...)

    Mots-clés Pascal : Cirrhose biliaire, Primitif, Asymptomatique, Exploration clinique, Prévalence, Traitement, Chimiothérapie, Etude longitudinale, Pronostic, Homme, Canada, Amérique du Nord, Amérique, Appareil digestif pathologie, Foie pathologie, Voie biliaire pathologie, Immunopathologie, Maladie autoimmune

    Mots-clés Pascal anglais : Biliary cirrhosis, Primitive, Asymptomatic, Clinical investigation, Prevalence, Treatment, Chemotherapy, Follow up study, Prognosis, Human, Canada, North America, America, Digestive diseases, Hepatic disease, Biliary tract disease, Immunopathology, Autoimmune disease

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 99-0119721

    Code Inist : 002B13C03. Création : 16/11/1999.