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  1. Cutaneous malignant melanoma in Swedish children and teenagers 1973-1992 : A clinico-pathological study of 130 cases.

    Article - En anglais

    To assess whether there has been a change in histological features and prognostic factors of primary cutaneous malignant melanoma (CMM) in young individuals in Sweden, an unselected, population-based study was undertaken ; 177 cases of primary CMM in persons below 20 years of age were reported to the Swedish National Cancer Registry between 1973 and 1992.

    In 87% of the cases, original tumor tissue was available for histo-pathological review.

    The original diagnosis was verified in 88% (n=126) of these cases.

    All tumors had histological features similar to adult CMM ; 17% had an associated precursor lesion.

    Superficial spreading melanoma (SSM) was the most common sub-type, constituting 20136 cases in the first decade and 59/90 in the second.

    Corresponding figures for nodular melanoma (NM) were 11/36 and 23190.

    Only 5 melanomas in situ were diagnosed.

    In girls, the mean thickness of SSM decreased from 1.5 to 0.6 mm (p<0.001).

    Overall mortality was 10%, 22% in the group with CMM diagnosed 0-15 years of age and 8% in individuals 15-19 years.

    Fatal CMM cases diagnosed below 15 years of age (n=4) were NM>1.6 mm thick and in subjects 15-1 years (n=9) 44% of fatal tumors were NM with a mean thickness of 2.2 mm.

    Breslow index was the single most important prognostic factor. (...)

    Mots-clés Pascal : Mélanome, Peau, Type histologique, Histopathologie, Epaisseur, Mortalité, Age, Pronostic, Epidémiologie, Suède, Europe, Enfant, Homme, Adolescent, Tumeur maligne, Peau pathologie, Anatomopathologie, Indice Breslow

    Mots-clés Pascal anglais : Melanoma, Skin, Histological type, Histopathology, Thickness, Mortality, Age, Prognosis, Epidemiology, Sweden, Europe, Child, Human, Adolescent, Malignant tumor, Skin disease, Pathology

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 99-0118914

    Code Inist : 002B08A. Création : 16/11/1999.