To assess whether there has been a change in histological features and prognostic factors of primary cutaneous malignant melanoma (CMM) in young individuals in Sweden, an unselected, population-based study was undertaken ; 177 cases of primary CMM in persons below 20 years of age were reported to the Swedish National Cancer Registry between 1973 and 1992.
In 87% of the cases, original tumor tissue was available for histo-pathological review.
The original diagnosis was verified in 88% (n=126) of these cases.
All tumors had histological features similar to adult CMM ; 17% had an associated precursor lesion.
Superficial spreading melanoma (SSM) was the most common sub-type, constituting 20136 cases in the first decade and 59/90 in the second.
Corresponding figures for nodular melanoma (NM) were 11/36 and 23190.
Only 5 melanomas in situ were diagnosed.
In girls, the mean thickness of SSM decreased from 1.5 to 0.6 mm (p<0.001).
Overall mortality was 10%, 22% in the group with CMM diagnosed 0-15 years of age and 8% in individuals 15-19 years.
Fatal CMM cases diagnosed below 15 years of age (n=4) were NM>1.6 mm thick and in subjects 15-1 years (n=9) 44% of fatal tumors were NM with a mean thickness of 2.2 mm.
Breslow index was the single most important prognostic factor. (...)
Mots-clés Pascal : Mélanome, Peau, Type histologique, Histopathologie, Epaisseur, Mortalité, Age, Pronostic, Epidémiologie, Suède, Europe, Enfant, Homme, Adolescent, Tumeur maligne, Peau pathologie, Anatomopathologie, Indice Breslow
Mots-clés Pascal anglais : Melanoma, Skin, Histological type, Histopathology, Thickness, Mortality, Age, Prognosis, Epidemiology, Sweden, Europe, Child, Human, Adolescent, Malignant tumor, Skin disease, Pathology
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0118914
Code Inist : 002B08A. Création : 16/11/1999.