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  1. Cholecystectomy and the risk of colon cancer.

    Article - En anglais

    Objective 

    The relationship between cholecystectomy and the occurrence of subsequent colon cancer has been controversial.

    Using data collected as part of an incident case-control study of colon cancer conducted in northern California, Minnesota, and Utah, we evaluated this association.

    Methods 

    Participants were between 30 and 79 yr of age and had a first primary colon cancer diagnosed between October 1,1991 and September 30,1994.

    Analyses were adjusted for age, gender, family history of colorectal cancer, body mass index, dietary energy and fiber intake, use of aspirin or nonsteroidal antiinflammatory drugs, and long-term leisure-time vigorous physical activity.

    Results 

    A weak positive association between cholecystectomy and proximal colon cancer (odds ratio [OR] and 95% confidence interval [CI] 1.3 [1.0-1.6]) was observed.

    This was counterbalanced by a weak, nonsignificant negative association (OR 0.8,95% CI 0.6-1.1) with distal colon cancer leading to no overall association (OR 1.0,95% CI 0.9-1.2).

    The association between colon cancer and cholecystectomy did not differ by gender or race, but it did differ by study area, with most of the increased association being attributed to the Minnesota population.

    The elevated risk of proximal colon cancer increased after cholecystectomy but disappeared after 14 years. (...)

    Mots-clés Pascal : Cholécystectomie, Epidémiologie, Facteur risque, Carcinome, Côlon, Etude multicentrique, Etude cas témoin, Association, Evaluation, Etats Unis, Amérique du Nord, Amérique, Homme, Vésicule biliaire, Chirurgie, Tumeur maligne, Appareil digestif pathologie, Intestin pathologie, Côlon pathologie

    Mots-clés Pascal anglais : Cholecystectomy, Epidemiology, Risk factor, Carcinoma, Colon, Multicenter study, Case control study, Association, Evaluation, United States, North America, America, Human, Gallbladder, Surgery, Malignant tumor, Digestive diseases, Intestinal disease, Colonic disease

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 99-0118741

    Code Inist : 002B13B01. Création : 16/11/1999.