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  1. A study of adult T-cell leukemia/lymphoma incidence in central Brooklyn.

    Article - En anglais

    Adult T-cell leukemia/lymphoma (ATL), a rare outcome of infection with human T-lymphotropic virus (HTLV-I), is endemic in central Brooklyn, which has a large Caribbean migrant population.

    Previous studies have suggested that HTLV-I prevalence in central Brooklyn may be similar to that recorded in the Caribbean islands.

    We established a pilot I-year surveillance program to identify cases of ATL in 7 of 10 hospitals serving the residents of 18 zip codes of central Brooklyn with a combined population of 1,184,670.

    Of the 6,198 in-patient beds in the catchment area, approximately 83% were covered.

    Twelve incident cases of ATL were ascertained, all among persons of Afro-Caribbean descent, indicating an annual incidence in African-Americans in this community of approximately 3.2/100,000 person-years.

    Unexplained hypercalcemia was the most useful screening method, identifying 3 of 5 patients not referred for possible ATL by a local hematologist.

    The female : male ratio was 3 : 1. The age pattern was different from that reported in the Caribbean Basin and closer to the pattern seen in Japan.

    Our study supports evidence that HTLV-I infection and ATL are endemic in central Brooklyn and suggests that a more intensive surveillance program for this disease coupled with intervention efforts to reduce HTLV-I transmission are warranted.

    Mots-clés Pascal : Lymphome, Leucémie cellule T adulte, Virose, Infection, Virus HTLV1, Retroviridae, Virus, Incidence, Epidémiologie, New York, Etats Unis, Amérique du Nord, Amérique, Homme, Hémopathie maligne, Lymphome non hodgkinien, Lymphoprolifératif syndrome

    Mots-clés Pascal anglais : Lymphoma, Adult T cell leukemia, Viral disease, Infection, HTLV-I virus, Retroviridae, Virus, Incidence, Epidemiology, New York, United States, North America, America, Human, Malignant hemopathy, Non Hodgkin lymphoma, Lymphoproliferative syndrome

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 99-0118149

    Code Inist : 002B19B. Création : 16/11/1999.