A study of adult T-cell leukemia/lymphoma incidence in central Brooklyn.
Adult T-cell leukemia/lymphoma (ATL), a rare outcome of infection with human T-lymphotropic virus (HTLV-I), is endemic in central Brooklyn, which has a large Caribbean migrant population.
Previous studies have suggested that HTLV-I prevalence in central Brooklyn may be similar to that recorded in the Caribbean islands.
We established a pilot I-year surveillance program to identify cases of ATL in 7 of 10 hospitals serving the residents of 18 zip codes of central Brooklyn with a combined population of 1,184,670.
Of the 6,198 in-patient beds in the catchment area, approximately 83% were covered.
Twelve incident cases of ATL were ascertained, all among persons of Afro-Caribbean descent, indicating an annual incidence in African-Americans in this community of approximately 3.2/100,000 person-years.
Unexplained hypercalcemia was the most useful screening method, identifying 3 of 5 patients not referred for possible ATL by a local hematologist.
The female : male ratio was 3 : 1. The age pattern was different from that reported in the Caribbean Basin and closer to the pattern seen in Japan.
Our study supports evidence that HTLV-I infection and ATL are endemic in central Brooklyn and suggests that a more intensive surveillance program for this disease coupled with intervention efforts to reduce HTLV-I transmission are warranted.
Mots-clés Pascal : Lymphome, Leucémie cellule T adulte, Virose, Infection, Virus HTLV1, Retroviridae, Virus, Incidence, Epidémiologie, New York, Etats Unis, Amérique du Nord, Amérique, Homme, Hémopathie maligne, Lymphome non hodgkinien, Lymphoprolifératif syndrome
Mots-clés Pascal anglais : Lymphoma, Adult T cell leukemia, Viral disease, Infection, HTLV-I virus, Retroviridae, Virus, Incidence, Epidemiology, New York, United States, North America, America, Human, Malignant hemopathy, Non Hodgkin lymphoma, Lymphoproliferative syndrome
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0118149
Code Inist : 002B19B. Création : 16/11/1999.