The authors utilized a cohort study among Seattle injection drug users (IDUs) to assess whether participation in a syringe exchange program was associated with incidence of hepatitis B virus (HBV) and hepatitis C virus (HCV) infection.
Susceptible IDU subjects (187 seronegative for antibody to HCV, and 460 seronegative for core antibody to HBV) were identified in drug treatment, corrections, and social service agencies from June 1994 to January 1996, and followed for seroconversion one year later.
The subjects included in the analysis were Seattle-King County (Washington State) area IDUs enrolled in a larger multipurpose cohort study, the Risk Activity Variables, Epidemiology, and Network Study (RAVEN Study).
There were 39 HCV infections (20.9/100/year) and 46 HBV infections (10.0/100/year).
There was no apparent protective effect of syringe exchange against HBV (former exchange users, relative risk (RR)=0.68,95% confidence interval (Cl) 0.2-2.5 ; sporadic exchange users, RR=2.4,95% Cl 0.9-6.5 ; regular users, RR=1.81,95% Cl 0.7-4.8 ; vs.
RR=1.0 for nonusers of the exchange ; adjusted for daily drug injection).
Neither did the exchange protect against HCV infection (sporadic users, RR=2.6,95% Cl 0.8-8.5 ; regular users, RR=1.3,95% Cl 0.8-2.2 ; vs.
RR=1.0 for nonusers ; adjusted for recent onset of injection and syringe sharing prior to enrollment). (...)
Mots-clés Pascal : Hépatite virale B, Virose, Infection, Hépatite virale C, Toxicomanie, Voie intraveineuse, Seringue, Programme sanitaire, Epidémiologie, Facteur risque, Incidence, Prévention, Homme, Etats Unis, Amérique du Nord, Amérique, Education santé, Evaluation, Appareil digestif pathologie, Foie pathologie
Mots-clés Pascal anglais : Viral hepatitis B, Viral disease, Infection, Viral hepatitis C, Drug addiction, Intravenous administration, Syringe, Sanitary program, Epidemiology, Risk factor, Incidence, Prevention, Human, United States, North America, America, Health education, Evaluation, Digestive diseases, Hepatic disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0114555
Code Inist : 002B05C02G. Création : 16/11/1999.