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  1. Nicotine nasal spray with nicotine patch for smoking cessation : randomised trial with six year follow up. Commentary.

    Article - En anglais

    Objective To evaluate the efficacy of using a nicotine patch for 5 months with a nicotine nasal spray for 1 year.

    Design Placebo controlled, double blind trial

    Setting Reykjavik health centre.

    Subjects 237 smokers aged 22-66 years living in or around Reykjavik.

    Interventions Nicotine patch for 5 months with nicotine nasal spray for 1 year (n=118) or nicotine patch with placebo spray. (n=119).

    Treatment with patches included 16 mg of nicotine for 3 months, 10 mg for the fourth month, and 5 mg for the fifth month, whereas nicotine in the nasal spray was available for up to 1 year.

    Both groups received supportive treatment.

    Main outcome measure Sustained abstinence from smoking.

    Results The log rank test for 6 years (X2=8.5, P=0.004) shows a significant association between abstinence from smoking and type of treatment Sustained abstinence rates for the patch and nasal spray group and patch only group were 51% v 35% after 6 weeks (P=0.011 (X2), 95% confidence interval 1.17%) to 3.32%), 37%1 v 25% after 3 months (P=0.045,1.01% to 3.08%), 31% v 16% after 6 months (P=0.005,1.27% to 4.50%), 27% v 11% after 12 months (P=0.001,1.50% to 6.14%), and 16% v 9% after 6 years (P=0.077,0.93% to 4.72%). Conclusions Short and long term abstinence rates show that the combination of using a nicotine patch for 5 months with a nicotine nasal spray for 1 year is a more effective method of stopping smoking than using a patch only. (...)

    Mots-clés Pascal : Tabagisme, Sevrage toxique, Tabac, Patch, Forme nasale, Nicotine, Traitement, Efficacité traitement, Homme, Essai thérapeutique contrôlé, Islande, Iles Atlantiques

    Mots-clés Pascal anglais : Tobacco smoking, Detoxification, Tobacco, Patch, Nasal form, Nicotine, Treatment, Treatment efficiency, Human, Controlled therapeutic trial, Iceland, Atlantic Ocean Islands

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 99-0113568

    Code Inist : 002B18I15. Création : 16/11/1999.