Oral clefts, transforming growth factor alpha gene variants, and maternal smoking : A population-based case-control study in Denmark, 1991-1994.
Studies in the United States have indicated that maternal first trimester smoking and infant transforming growth factor alpha (TGFA) locus mutations are associated with non-syndromic cleft lip and/or palate (CLP) and that a synergistic effect of these two risk factors occurs.
Based on a Danish case-control study of CLP, the authors studied the effects of smoking and TGFA alleles in an ethnically homogeneous setting.
Interview information was obtained for mothers of 302 CLP cases (96% of eligible) and for 567 mothers of nonmalformed children (94% of eligible).
Multivariate logistic regression analyses revealed that smoking was associated with a moderately increased risk of cleft lip ± cleft palate (CL (P)) (odds ratio=1.40,95% confidence interval 0.99-2.00).
No association between smoking and isolated cleft palate (CP) was observed.
TGFA genotype was not associated with either CL (P) or CP, and no synergistic effect with smoking was observed.
The « rare » TGFA allele occurred in 25% of both cases and controls compared with an average of 14% in other white control groups.
Furthermore, the frequency of CLP in Scandinavia is among the highest in the world.
Hence, it is possible that the previously reported association between TGFA and CLP to some degree can be attributable to confounding by ethnicity.
Mots-clés Pascal : Bec de lièvre, Facteur croissance transformant alpha, Allèle, Génétique, Tabagisme, Mère, Exposition, Epidémiologie, Facteur risque, Enfant, Homme, Etude cas témoin, Danemark, Europe, Santé et environnement, Malformation, Maladie congénitale
Mots-clés Pascal anglais : Cleft lip, Transforming growth factor alpha, Allele, Genetics, Tobacco smoking, Mother, Exposure, Epidemiology, Risk factor, Child, Human, Case control study, Denmark, Europe, Health and environment, Malformation, Congenital disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0113563
Code Inist : 002B30A01A2. Création : 16/11/1999.