Lymphocyte subsets in healthy children are currently characterized by age-related standards.
Because antigenic stimuli play a role in maturation of the immune system after birth, there is a question of whether cellular immune development differs in infants whose living conditions entail extensive antigenic exposure and infants growing up in a more protected environment.
Peripheral blood lymphocyte subsets were studied in two populations of children of similar age and nutritional status ; children belonging to a rural population residing in proximity with farm animals and children from an economically privileged urban population.
In each population, children studied included a group with an acute diarrheal episode and a healthy control group.
Among rural population children, 65% had experienced at least one episode of gastroenteritis within the previous 3-month-period, compared with less than 10% of urban population children.
In the rural population group 15% had experienced two or more episodes of gastroenteritis.
The proportion of helper T cells was similar in rural population and urban population children.
Among helper T cells, the proportion of CD29+ « memory » cells of the total CD4+helper T cells was more than two times higher than those in rural population children.
The proportion of CD8 cells was higher in rural population children than in urban population children, and the proportion of natural killer cells. (...)
Mots-clés Pascal : Développement, Immunité, Réponse immune, Effet environnement, Facteur milieu, Multiplicité, Antigène, Milieu rural, Sous population cellulaire, Lymphocyte, Epidémiologie, Individu sain, Enfant, Homme, Immunologie
Mots-clés Pascal anglais : Development, Immunity, Immune response, Environmental effect, Environmental factor, Multiplicity, Antigen, Rural environment, Cell subpopulation, Lymphocyte, Epidemiology, Healthy subject, Child, Human, Immunology
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0109332
Code Inist : 002B30A01A2. Création : 16/11/1999.