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  1. Dose dependent reduction of erythroid progenitor cells and inappropriate erythropoietin response in exposure to lead : new aspects of anaemia induced by lead.

    Article - En anglais

    Objective

    To determine whether haematopoietic progenitor cells and erythropoietin (EPO), which is an essential humoral stimulus for erythroid progenitor (BFU-E) cell differentiation, are affected by lead intoxication.

    Methods-In male subjects chronically exposed to lead with and without anaemia, pluripotent (CFU-GEMM), BFU-E and granulocyte/macrophage (CFU-GM) progenitor cell counts in peripheral blood were measured with a modified clonal assay.

    Lead concentrations in blood (PbB) and urine (PbU) were measured by the atomic absorption technique, and EPO was measured with a modified radioimmunoassay.

    Results

    PbB in the subjects exposed to lead ranged from 0.796 to 4.4 mumol/l, and PbU varied between 0.033 and 0.522 mumol/l. In subjects exposed to lead with PbB >= 2.896 mumol/l (n=7), BFU-E cells were significantly reduced (p<0.001) whereas the reduction in CFU-GM cells was only of borderline significance (p=0.037) compared with the age matched controls (n=20).

    The CFU-GEMM cells remained unchanged

    Furthermore, BFU-E and CFU-GM cells were reduced in a dose dependent fashion, with increasing PbB or PbU, respectively.

    In the subjects exposed to lead EPO was in the normal range and did not increase in the presence of anaemia induced by lead.

    No correlations existed between EPO and PbB, PbU, or progenitor cells. (...)

    Mots-clés Pascal : Plomb, Métal lourd, Exposition professionnelle, Médecine travail, Industrie, Cellule BFU-E, Toxicité, Homme, Erythropoïétine, Surveillance biologique, Marqueur biologique, Liquide biologique, Sang, Etude cas témoin

    Mots-clés Pascal anglais : Lead, Heavy metal, Occupational exposure, Occupational medicine, Industry, BFU-E-Cell, Toxicity, Human, Erythropoietin, Biological monitoring, Biological marker, Biological fluid, Blood, Case control study

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 99-0108998

    Code Inist : 002B03L05. Création : 16/11/1999.