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  1. Fulltext. Protection against influenza after annually repeated vaccination : A meta-analysis of serologic and field studies.

    Article - En anglais



    According to common recommendations, influenza vaccination should be performed annually.

    It has been suggested that vaccination in previous years reduces vaccine efficacy in the long term.


    To determine whether the protection of influenza vaccine decreases when vaccination is repeated annually.


    Articles published between 1966 and 1997 were selected from MEDLINE.

    The end point for field studies was the influenza-related morbidity or mortality during influenza outbreaks (resulting in field protection rates).

    The end point for serologic studies was exceeding a protective postvaccination hemagglutination-inhibition titer (serologic protection rates).

    Protection rate differences between groups with single and multiple vaccinations were subjected to meta-analysis.


    Seven field studies (including 13 trials) supported the hypothesis that protection in multiple-vaccination groups is at least as good as that in single-vaccination groups.

    Ten trials with 511 7 observations could be subjected to meta-analysis.

    The pooled protection-rate difference was close to 0 (1.1% ; 95% confidence interval, - 0.2% to 2.4%), thus detecting no difference between single or multiple vaccination. (...)

    Mots-clés Pascal : Grippe, Virose, Infection, Epidémiologie, Sérologie, Vaccination, Moyenne annuelle, Répétition, Evaluation, Métaanalyse, Efficacité traitement, Long terme, Etude cohorte, Homme, Immunoprophylaxie, Prévention

    Mots-clés Pascal anglais : Influenza, Viral disease, Infection, Epidemiology, Serology, Vaccination, Annual average, Repetition, Evaluation, Metaanalysis, Treatment efficiency, Long term, Cohort study, Human, Immunoprophylaxis, Prevention

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 99-0108645

    Code Inist : 002B05A02. Création : 16/11/1999.