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  1. Fulltext. Clinical and economic effects of population-based Helicobacter pylori screening to prevent Gastric cancer.

    Article - En anglais

    Fulltext.

    Background 

    Helicobacter pylori infection has been identified as a risk factor for certain types of gastric cancer.

    However, the extent to which H pylori eradication decreases the risk of gastric cancer is unknown, raising the question of whether population-based H pylori screening should be undertaken.

    Objective 

    To compare clinical and economic effects of H pylori screening, with and without confirmatory testing. with no screening to prevent gastric cancer.

    Design 

    Decision analysis incorporating a Markov simulation.

    Patients 

    Simulated cohorts of men and women with varying risk of gastric cancer.

    Intervention 

    Three strategies were evaluated :

    • (1) no screening ;

    • (2) H pylori serologic testing, treat those positive for H pylori, no follow-up testing ;

    • and (3) H pylori serologic testing, treat those positive for H pylori, followed by a test to confirm H pylori eradication, retreat those who test positive.

    In the principal analysis, the risk of gastric cancer after H pylori eradication was assumed to be similar to that for those without H pylor infection.

    Scenarios with less optimistic assumptions regarding risk reduction of cancer were evaluated.

    Main Outcome Measures 

    Gastric cancer rates, discounted cost per life-year saved. (...)

    Mots-clés Pascal : Helicobacter pylori, Spirillaceae, Spirillales, Bactérie, Dépistage, Prévention, Carcinome, Estomac, Stratégie, Sérologie, Etude comparative, Biologie clinique, Analyse avantage coût, Eradication, Homme, Evaluation, Etats Unis, Amérique du Nord, Amérique, Bactériose, Infection, Appareil digestif pathologie, Estomac pathologie, Tumeur maligne, Biochimie, Economie santé

    Mots-clés Pascal anglais : Helicobacter pylori, Spirillaceae, Spirillales, Bacteria, Medical screening, Prevention, Carcinoma, Stomach, Strategy, Serology, Comparative study, Clinical biology, Cost benefit analysis, Eradication, Human, Evaluation, United States, North America, America, Bacteriosis, Infection, Digestive diseases, Gastric disease, Malignant tumor, Biochemistry, Health economy

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 99-0108621

    Code Inist : 002B05B02F. Création : 16/11/1999.