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  1. Paternal exposure to pesticides and congenital malformations.

    Article - En anglais

    Objectives A case-referent study with 261 matched pairs was carried out in 8 hospitals of Comunidad Valenciana, Spain, to assess the relation between occupational exposure to pesticides and selected congenital malformations.

    In this paper, the results concerning paternal exposure are presented.

    Methods The parents of the case patients and the referents were interviewed to collect information about exposure to pesticides and potential confounding variables.

    Detailed information on direct involvement in the handling of pesticides was collected for the interviewees involved in agricultural activities during a previously defined period in relation to conception and pregnancy.

    Exposure data were reviewed by 2 experts who assigned ordinal scores for the probability and intensity of exposure to pesticide classes and active ingredients.

    Results The dichotomous analysis of exposure (absent, present) yielded some increased risks, although not statistically significant, for aliphatic hydrocarbons [adjusted odds ratio (adjusted OR) 2.05,95% confidence interval (95% CI) 0.62-6.80], inorganic compounds (adjusted OR 2.02,95% CI 0.53-7.72), and glufosinate (adjusted OR 2.45,95% CI 0.78-7.70), and a significant association for pyridil derivatives (adjusted OR 2.77,95% CI 1.19-6.44).

    The analysis based on the experts'scores (2 levels of exposure) showed some consistent associations for these compounds. (...)

    Mots-clés Pascal : Exposition professionnelle, Médecine travail, Pesticide, Agriculteur, Homme, Toxicité, Descendance, Malformation, Epidémiologie, Espagne, Europe, Origine paternelle, Analyse statistique, Facteur risque, Evaluation

    Mots-clés Pascal anglais : Occupational exposure, Occupational medicine, Pesticides, Farmer, Human, Toxicity, Progeny, Malformation, Epidemiology, Spain, Europe, Paternal origin, Statistical analysis, Risk factor, Evaluation

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 99-0108071

    Code Inist : 002B03G. Création : 16/11/1999.