Objectives The possible etiologic relevance of occupational factors such as cadmium, cutting oils, diesel fuel and fumes, herbicides, polycyclic aromatic hydrocarbons (PAH), polychlorinated biphenyls, soot, tar, mineral oil, and solvents to prostate cancer was studied.
Methods A case-referent study design was used to recruit 192 subjects with histologically confirmed prostate cancer and 210 referents who had prostate cancer histologically excluded either in one of two urologic practices (Hamburg and Frankfurt) or in the urological policlinic of the Frankfurt University.
Data were gathered with a self-administered questionnaire and analyzed using logistic regression to control for age, region, and cigarette smoking.
A job-exposure matrix was used for assigning exposure.
For the calculation of dose-years, the duration of contact with specific substances was weighted by the intensity and probability of exposure according to a job-exposure matrix.
Results The analysis of dose-years yielded a statistically significant association between occupational exposure to diesel fuel or fumes and prostate cancer (odds ratio 3.7,95% confidence interval 1.4-9.8, for subjects exposed to more than 25 dose-years in a comparison with subjects never exposed).
For the other substances, no statistically significant differences in exposure were found between the cases and referents. (...)
Mots-clés Pascal : Exposition professionnelle, Médecine travail, Carburant diesel, Composé aromatique polycyclique, Composé chimique, Tumeur maligne, Prostate, Homme, Etude cas témoin, Epidémiologie, Allemagne, Europe, Régression logistique, Facteur risque, Evaluation, Analyse statistique, Appareil génital mâle pathologie, Appareil urinaire pathologie, Prostate pathologie
Mots-clés Pascal anglais : Occupational exposure, Occupational medicine, Diesel fuel, Polycyclic aromatic compound, Chemical compound, Malignant tumor, Prostate, Human, Case control study, Epidemiology, Germany, Europe, Logistic regression, Risk factor, Evaluation, Statistical analysis, Male genital diseases, Urinary system disease, Prostate disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0108063
Code Inist : 002B03L02. Création : 16/11/1999.